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KMID : 0861020030180020101
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Korea Journal of Herbology
2003 Volume.18 No. 2 p.101 ~ p.108
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The Effect of Pear Pectin &. Phenolic Compounds on Regional Cerebral Blood Flow, Mean Arterial Blood Pressure, Heart Rate and Cardiac Contractile Force in Hypertensive Rat Induced by 2K1C
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Abstract
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Objectives : Oriental pear was used as treating disorder of heart and blood circulation in oriental medicine. This study was designed to investigate that pear pectin, pear phenolic compound effects on cardiovascular system as regional cerebral blood flow(rCBF), mean arterial blood pressure(MAP), heart rate, cardiac contractile force.
Methods : The experiments were performed on Sprague Dawley rats. 2K1C hypertension model was prepared by constricting the left renal artery with a sliver clip. Apple pectin, pear pectin and pear phenolic compound solutions were administrated via femoral vein for Sweeks, a day´s interval. Animals were divided into four groups, administration of apple pectin(AP1, pear pectin(PP) and pear phenolic compound( PPC ).
Results : The results are that KBF was significantly increased at lmglkg in PPC group. The MAP was significantly decreased at l0㎍/kg in apple pectin, at l0㎍/kg, 100㎍/kg in pear pecitn than before adminstration, but increased at 1 m p d k g in pear phenolic compound. There was no significant effects in heart rate. Cardiac contractile force was significantly increased a at l0㎍/kg, l00㎍/kg, lmg/kg in pear phenolic compound.
Conclusions : These results suggests that pear phenolic compound and pear pectin may be a significant effect in symptoms of heart and blood circulation..
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